Mme Cécilia Hognon
Post-Doctorant University Paris CitéCiTCoMBiographical Info
Research :
- Molecular modelling (all atom, QM, QM/MM)
- Protein-protein, protein RNA or DNA interaction
- SHAPE reactivity
- Nucleic acid
Publications :
24 documents
Journal articles
- Cécilia Hognon, Emmanuelle Bignon, Antonio Monari, Marco Marazzi, Cristina Garcia-Iriepa. Revealing the Molecular Interactions between Human ACE2 and the Receptor Binding Domain of the SARS-CoV-2 Wild-Type, Alpha and Delta Variants. International Journal of Molecular Sciences, 2023, 24 (3), pp.2517. ⟨10.3390/ijms24032517⟩. ⟨hal-04150197⟩
- Anne-Sophie Banneville, Claire Bouthier de La Tour, Cécilia Hognon, Jacques-Philippe Colletier, Jean-Marie Teulon, et al.. Structural and functional characterization of DdrC, a novel DNA damage-induced nucleoid associated protein involved in DNA compaction. Nucleic Acids Research, 2022, 50 (13), pp.7680-7696. ⟨10.1093/nar/gkac563⟩. ⟨hal-03420989⟩
- Jeremy Morere, Cécilia Hognon, Tom Miclot, Tao Jiang, Elise Dumont, et al.. How Fragile We Are: Influence of Stimulator of Interferon Genes (STING) Variants on Pathogen Recognition and Immune Response Efficiency. Journal of Chemical Information and Modeling, 2022, 62 (12), pp.3096-3106. ⟨10.1021/acs.jcim.2c00315⟩. ⟨hal-04157319⟩
- Tom Miclot, Cécilia Hognon, Emmanuelle Bignon, Alessio Terenzi, Stéphanie Grandemange, et al.. Never cared for what they do: High structural stability of Guanine-Quadruplexes in the presence of strand-break damage. Molecules, 2022, 27 (10), pp.3256. ⟨10.3390/molecules27103256⟩. ⟨hal-03925687⟩
- Cécilia Hognon, Marco Marazzi, Cristina García-Iriepa. Atomistic-Level Description of the Covalent Inhibition of SARS-CoV-2 Papain-like Protease. International Journal of Molecular Sciences, 2022, 23 (10), pp.5855. ⟨10.3390/ijms23105855⟩. ⟨hal-04150210⟩
- Janske Nel, David Siniscalco, Cécilia Hognon, Mathilde Bouché, Nadège Touche, et al.. Structural and morphological changes of breast cancer cells induced by iron (II) complexes. Nanoscale, 2022, 14 (7), pp.2735-2749. ⟨10.1039/D1NR08301E⟩. ⟨hal-03563765⟩
- Nour-El-Houda Hammoudi, Yacine Benguerba, Ayoub Attoui, Cecilia Hognon, Tarek Lemaoui, et al.. In silico drug discovery of IKK-β inhibitors from 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl) pyridine derivatives based on QSAR, docking, molecular dynamics and drug-likeness evaluation studies. Journal of Biomolecular Structure and Dynamics, 2022, 40 (2), pp.886-902. ⟨10.1080/07391102.2020.1819878⟩. ⟨hal-04157330⟩
- Antonio Francés-Monerris, Cristina García-Iriepa, Isabel Iriepa, Cécilia Hognon, Tom Miclot, et al.. Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection. Physical Chemistry Chemical Physics, 2021, 23 (40), pp.22957-22971. ⟨10.1039/D1CP02967C⟩. ⟨hal-03753387⟩
- Cécilia Hognon, Emmanuelle Bignon, Guillaume Harle, Nadège Touche, Stéphanie Grandemange, et al.. The iron maiden. Cytosolic aconitase/IRP1 conformational transition in the regulation of ferritin translation and iron hemostasis. Biomolecules, 2021, 11 (9), pp.1329. ⟨10.3390/biom11091329⟩. ⟨hal-03503702⟩
- Cécilia Hognon, Antonio Monari. Staring at the Naked Goddess: Unraveling the Structure and Reactivity of Artemis Endonuclease Interacting with a DNA Double Strand. Molecules, 2021, 26 (13), pp.3986. ⟨10.3390/molecules26133986⟩. ⟨hal-03753201⟩
- Tom Miclot, Camille Corbier, Alessio Terenzi, Cécilia Hognon, Stéphanie Grandemange, et al.. Forever young: Structural stability of telomeric guanine quadruplexes in the presence of oxidative DNA lesions. Chemistry - A European Journal, 2021, 27 (34), pp.8865-8874. ⟨10.1002/chem.202100993⟩. ⟨hal-03503711⟩
- Tom Miclot, Cécilia Hognon, Emmanuelle Bignon, Alessio Terenzi, Marco Marazzi, et al.. Structure and Dynamics of RNA Guanine Quadruplexes in SARS-CoV-2 Genome. Original Strategies against Emerging Viruses. Journal of Physical Chemistry Letters, 2021, 12 (42), pp.10277--10283. ⟨10.1021/acs.jpclett.1c03071⟩. ⟨hal-03786805⟩
- Antonio Francés‐monerris, Cécilia Hognon, Thierry Douki, Antonio Monari. Photoinduced DNA Lesions in Dormant Bacteria: The Peculiar Route Leading to Spore Photoproducts Characterized by Multiscale Molecular Dynamics. Chemistry - A European Journal, 2020, 26 (62), pp.14236-14241. ⟨10.1002/chem.202002484⟩. ⟨hal-03065911⟩
- Antonio Francés-Monerris, Cécilia Hognon, Tom Miclot, Cristina García-Iriepa, Isabel Iriepa, et al.. Molecular basis of SARS-CoV-2 infection and rational design of potential antiviral agents: Modeling and simulation approaches. Journal of Proteome Research, 2020, 19 (11), pp.4291-4315. ⟨10.1021/acs.jproteome.0c00779⟩. ⟨hal-03503722⟩
- Cristina García-Iriepa, Cécilia Hognon, Antonio Francés-Monerris, Isabel Iriepa, Tom Miclot, et al.. Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-Converting Enzyme 2. Effects of Possible Ligands. Journal of Physical Chemistry Letters, 2020, 11 (21), pp.9272-9281. ⟨10.1021/acs.jpclett.0c02203⟩. ⟨hal-04157339⟩
- Mathilde Bouché, Cécilia Hognon, Stéphanie Grandemange, Antonio Monari, Philippe Gros. Recent advances in iron-complexes as drug candidates for cancer therapy: reactivity, mechanism of action and metabolites. Dalton Transactions, 2020, 49 (33), pp.11451-11466. ⟨10.1039/D0DT02135K⟩. ⟨hal-02915892⟩
- Cécilia Hognon, Tom Miclot, Cristina García-Iriepa, Antonio Francés-Monerris, Stéphanie Grandemange, et al.. Role of RNA guanine quadruplexes in favoring the dimerization of SARS unique domain in coronaviruses. Journal of Physical Chemistry Letters, 2020, 11 (14), pp.5661-5667. ⟨10.1021/acs.jpclett.0c01097⟩. ⟨hal-02912974⟩
- Cécilia Hognon, Simon Garaude, Joanna Timmins, Christophe Chipot, Francois Dehez, et al.. Molecular Basis of DNA Packaging in Bacteria Revealed by All-Atoms Molecular Dynamic Simulations: The case of histone like proteins in Borrelia burgdoferi.. Journal of Physical Chemistry Letters, 2019, ⟨10.1021/acs.jpclett.9b02978⟩. ⟨hal-02352618⟩
- Cécilia Hognon, Adrien Gebus, Giampaolo Barone, Antonio Monari. Human DNA Telomeres in Presence of Oxidative Lesions: The Crucial Role of Electrostatic Interactions on the Stability of Guanine Quadruplexes. Antioxidants , 2019, ⟨10.3390/antiox8090337⟩. ⟨hal-02269375⟩
- Cécilia Hognon, Vanessa Besancenot, Arnaud Gruez, Stéphanie Grandemange, Antonio Monari. Cooperative effects of cytosine methylation on DNA structure and dynamics. Journal of Physical Chemistry B, 2019, 123 (34), pp.7365-7371. ⟨10.1021/acs.jpcb.9b05835⟩. ⟨hal-02227499⟩
- Aili Sarre, Meike Stelter, Filipe Rollo, Salvatore Debonis, Anna Seck, et al.. The three Endonuclease III variants of Deinococcus radiodurans possess distinct and complementary DNA repair activities. DNA Repair, 2019, 78, pp.45-59. ⟨10.1016/j.dnarep.2019.03.014⟩. ⟨hal-02092591⟩
- Antonio Francés-Monerris, Cécilia Hognon, Miguel Miranda, Virginie Lhiaubet-Vallet, Antonio Monari. Triplet photosensitization mechanism of thymine by an oxidized nucleobase: from a dimeric model to DNA environment. Physical Chemistry Chemical Physics, 2018, 20 (40), pp.25666-25675. ⟨10.1039/C8CP04866E⟩. ⟨hal-02184616⟩
Preprints, Working Papers
- Afra Sabei, Cécilia Hognon, Juliette Martin, Elisa Frezza. The dynamics of protein-RNA interfaces using all-atom molecular dynamics simulations. 2024. ⟨hal-04479270⟩
Theses
- Cécilia Hognon. Modélisation et simulation moléculaire pour la compréhension des processus biologiques fondamentaux et le développement de nouveaux agents thérapeutiques contre le cancer et la Covid-19. Biologie cellulaire. Université de Lorraine, 2021. Français. ⟨NNT : 2021LORR0233⟩. ⟨tel-03508945⟩
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