M Ludovic Jean

Ophélie da Silva, Nicolas Probst, Christophe Landry, Anne-Sophie Hanak, Pierre Warnault, et al.. A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning. Journal of Medicinal Chemistry, 2022, 65 (6), pp.4649-4666. ⟨10.1021/acs.jmedchem.1c01748⟩. ⟨hal-03706969⟩
Elisabet Viayna, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Pedro Cisternas, Carolina Oliva, et al.. Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice. Journal of Medicinal Chemistry, 2020, ⟨10.1021/acs.jmedchem.0c01775⟩. ⟨hal-03094189⟩
Monika Cieslikiewicz-Bouet, Marina Naldi, Manuela Bartolini, Belén Pérez, Denis Servent, et al.. Functional characterization of multifunctional ligands targeting acetylcholinesterase and alpha 7 nicotinic acetylcholine receptor. Biochemical Pharmacology, 2020, 177, ⟨10.1016/j.bcp.2020.114010⟩. ⟨hal-02560260⟩
Tamara Zorbaz, Petra Mišetić, Nicolas Probst, Suzana Žunec, Antonio Zandona, et al.. Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning. ACS Chemical Neuroscience, 2020, 11 (7), pp.1072-1084. ⟨10.1021/acschemneuro.0c00032⟩. ⟨hal-02505607⟩
Pierrick Bruyat, Ludovic Jean, Pierre-Yves Renard. Regioselective Solid-Phase Synthesis of Peptide Analogues Containing 3,4- or 3,5-Disubstituted Isoxazole as s-cis or s-trans Peptide Bond Mimics. European Journal of Organic Chemistry, 2019, 2019 (20), pp.3134-3141. ⟨10.1002/ejoc.201900378⟩. ⟨hal-02319741⟩
Killian Oukoloff, Nicolas Coquelle, Manuela Bartolini, Marina Naldi, Rémy Le Guével, et al.. Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. European Journal of Medicinal Chemistry, 2019, 168, pp.58-77. ⟨10.1016/j.ejmech.2018.12.063⟩. ⟨hal-02055769⟩
Mégane Pons, Sylvie Chalon, Ludovic Jean, Pierre-Yves Renard, Frederic Buron, et al.. Toward an Innovative Treatment of Alzheimer’s Disease: Design of MTDLs Targeting Acetylcholinesterase and α-7 Nicotinic Receptors. Proceedings, 2019, 22 (1), pp.88. ⟨10.3390/proceedings2019022088⟩. ⟨hal-02352595⟩
Pierrick Bruyat, Arnaud Gautier, Ludovic Jean, Pierre-Yves Renard. Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles. Journal of Organic Chemistry, 2018, 83 (21), pp.13515-13522. ⟨10.1021/acs.joc.8b01490⟩. ⟨hal-01916360⟩
Carles Galdeano, Nicolas Coquelle, Monika Cieslikiewicz-Bouet, Manuela Bartolini, Belén Pérez, et al.. Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis. Molecules, 2018, 23 (3), pp.634. ⟨10.3390/molecules23030634⟩. ⟨hal-01807857⟩
Gianluca Santoni, J. de Sousa, Eugenio de La Mora, J. Dias, Ludovic Jean, et al.. Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents. Journal of Medicinal Chemistry, 2018, 61 (17), pp.7630-7639. ⟨10.1021/acs.jmedchem.8b00592⟩. ⟨hal-02024531⟩
T.N. Pashirova, Anissa Braïki, I.V. Zueva, K.A. Petrov, V.M. Babaev, et al.. Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection. Journal of Controlled Release, 2018, 290, pp.102-111. ⟨10.1016/j.jconrel.2018.10.010⟩. ⟨hal-02024524⟩
Tamara Zorbaz, Anissa Braïki, Nikola Marakovic, Julien Renou, Eugenio de La Mora, et al.. Potent 3‐Hydroxy‐2‐Pyridine Aldoxime Reactivators of Organophosphate‐Inhibited Cholinesterases with Predicted Blood–Brain Barrier Penetration. Chemistry - A European Journal, 2018, 24 (38), pp.9675-9691. ⟨10.1002/chem.201801394⟩. ⟨hal-02024542⟩
Paul Hermant, Damien Bosc, Catherine Piveteau, Ronan Gealageas, Baovy Lam, et al.. Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox. Journal of Medicinal Chemistry, 2017, 60 (21), pp.9067-9089. ⟨10.1021/acs.jmedchem.7b01444⟩. ⟨hal-03054238⟩
Pierre-Yves Renard, Ludovic Jean. Selective and sensitive near‐infrared fluorescent probe for acetylcholinesterase imaging [abstract]. Journal of Neurochemistry, 2017, 142 (S2), pp.188-225. ⟨10.1111/jnc.13925⟩. ⟨hal-02329887⟩
André-Guilhem Calas, José Dias, Catherine Rousseau, Mélanie Arboléas, Mélanie Touvrey-Loiodice, et al.. An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice. Chemico-Biological Interactions, 2017, 267 (1), pp.11-16. ⟨10.1016/j.cbi.2016.03.009⟩. ⟨hal-02046266⟩
Pierre-Yves Renard, Ludovic Jean. Probing the cholinergic system to understand neurodegenerative diseases. Future Medicinal Chemistry, 2017, 9 (2), pp.131-133. ⟨10.4155/fmc-2016-0213⟩. ⟨hal-02046305⟩
Killian Oukoloff, Sovy Chao, Monika Cieslikiewicz-Bouet, Romain Mougeot, Ludovic Jean, et al.. Improved Access to Huprine Derivatives Functionalized at Position 9. European Journal of Organic Chemistry, 2016, 2016 (7), pp.1337-1343. ⟨10.1002/ejoc.201501433⟩. ⟨hal-02046230⟩
Julien Renou, José Dias, Guillaume Mercey, Tristan Verdelet, Catherine Rousseau, et al.. Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase. RSC Advances, 2016, 6 (22), pp.17929-17940. ⟨10.1039/c5ra25477a⟩. ⟨hal-02046237⟩
Sovy Chao, Eric Krejci, Véronique Bernard, Jacqueline Leroy, Ludovic Jean, et al.. A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging. Chemical Communications, 2016, 52 (77), pp.11599-11602. ⟨10.1039/c6cc05936h⟩. ⟨hal-03013508⟩
Rómulo Aráoz, Monika Bouet, Manuela Bartolini, Nicolas Coquelle, Jacques-Philippe Colletier, et al.. Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of α7 nicotinic acetylcholine receptor. Biochemical Pharmacology, 2015, 97 (4), pp.621. ⟨10.1016/j.bcp.2015.08.006⟩. ⟨hal-02329901⟩
Killian Oukoloff, Frederic Buron, Sylvain Routier, Ludovic Jean, Pierre-Yves Renard. Synthetic Route to Rare Isoindolones Derivatives. European Journal of Organic Chemistry, 2015, 2015 (11), pp.2450-2456. ⟨10.1002/ejoc.201403649⟩. ⟨hal-01150276⟩
Killian Oukoloff, Monika Cieslikiewicz-Bouet, Sovy Chao, Emilie da Costa Branquinho, C. Bouteiller, et al.. PET and SPECT radiotracers for Alzheimer's disease. Current Medicinal Chemistry, 2015, 22 (28), pp.3278-3304. ⟨10.2174/0929867322666150805094645⟩. ⟨hal-02046165⟩
Lucie Aliouane, Sovy Chao, Brizuela Leyre, Emmanuel Pfund, Cuvillier Olivier, et al.. Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1. Bioorganic and Medicinal Chemistry, 2014, 22 (17), pp.4955-4960. ⟨10.1016/j.bmc.2014.06.038⟩. ⟨hal-01063240⟩
Maria Kliachyna, Gianluca Santoni, Valentin Nussbaum, Julien Renou, Benoît Sanson, et al.. Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase. European Journal of Medicinal Chemistry, 2014, 78, pp.455-467. ⟨10.1016/j.ejmech.2014.03.044⟩. ⟨hal-01131268⟩
Emilia Oueis, Gianluca Santoni, Cyril Ronco, Olga A. Syzgantseva, Vincent Tognetti, et al.. Reaction site-driven regioselective synthesis of AChE inhibitors. Organic & Biomolecular Chemistry, 2014, 12 (1), pp.156-161. ⟨10.1039/C3OB42109K⟩. ⟨hal-02335933⟩
Julien Renou, Melanie Loiodice, Melanie Arboleas, Rachid Baati, Ludovic Jean, et al.. Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterase. Chemical Communications, 2014, 50 (30), pp.3947-3950. ⟨10.1039/C4CC00561A⟩. ⟨hal-01150284⟩
Florian Nachon, Eugénie Carletti, Cyril Ronco, Marie Trovaslet, Yvain Nicolet, et al.. Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.. Biochemical Journal, 2013, 453 (3), pp.393-399. ⟨10.1042/BJ20130013⟩. ⟨hal-00996550⟩
Emilie da Costa Branquinho, Guillaume Becker, Cédric Bouteiller, Ludovic Jean, Pierre-Yves Renard, et al.. Radiosynthesis and in vivo evaluation of fluorinated huprine derivates as PET radiotracers of acetylcholinesterase. Nuclear Medicine and Biology, 2013, 40 (4), pp.554-560. ⟨10.1016/j.nucmedbio.2013.02.004⟩. ⟨hal-00847401⟩
Julien Renou, Guillaume Mercey, Tristan Verdelet, Emilia Păunescu, Emilie Gillon, et al.. Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.. Chemico-Biological Interactions, 2013, 203 (1), pp.81-84. ⟨10.1016/j.cbi.2012.09.023⟩. ⟨hal-00996535⟩
Guillaume Mercey, Julien Renou, Tristan Verdelet, Maria Kliachyna, Rachid Baati, et al.. Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.. Journal of Medicinal Chemistry, 2012, 55 (23), pp.10791-10795. ⟨10.1021/jm3015519⟩. ⟨hal-00996512⟩
Anna Ziemianin, Cyril Ronco, Romain Dolé, Ludovic Jean, Pierre-Yves Renard, et al.. Screening of new huprines--inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2012, 70, pp.1-5. ⟨10.1016/j.jpba.2012.01.038⟩. ⟨hal-00996397⟩
Xavier Brazzolotto, Marielle Wandhammer, Cyril Ronco, Marie Trovaslet, Ludovic Jean, et al.. Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure.. FEBS Journal, 2012, 279 (16), pp.2905-2916. ⟨10.1111/j.1742-4658.2012.08672.x⟩. ⟨hal-00996490⟩
Guillaume Mercey, Tristan Verdelet, Julien Renou, Maria Kliachyna, Rachid Baati, et al.. Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. Accounts of Chemical Research, 2012, 45 (5), pp.756-766. ⟨10.1021/ar2002864⟩. ⟨hal-01015972⟩
Cyril Ronco, Eugénie Carletti, Jacques-Philippe Colletier, Martin Weik, Florian Nachon, et al.. Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.. ChemMedChem, 2012, 7 (3), pp.400-405. ⟨10.1002/cmdc.201100438⟩. ⟨hal-00996475⟩
Guillaume Mercey, Tristan Verdelet, Géraldine Saint-André, Emilie Gillon, Alain Wagner, et al.. First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.. Chemical Communications, 2011, 47 (18), pp.5295-5297. ⟨10.1039/c1cc10787a⟩. ⟨hal-00991912⟩
Cyril Ronco, Richard Foucault, Emilie Gillon, Pierre Bohn, Florian Nachon, et al.. New huprine derivatives functionalized at position 9 as highly potent acetylcholinesterase inhibitors.. ChemMedChem, 2011, 6 (5), pp.876-888. ⟨10.1002/cmdc.201000523⟩. ⟨hal-00991920⟩
Nicolas Maindron, Séverine Poupart, Maxime Hamon, Jean-Baptiste Langlois, Nelly Plé, et al.. Synthesis and luminescence properties of new red-shifted absorption lanthanide(III) chelates suitable for peptide and protein labelling.. Organic & Biomolecular Chemistry, 2011, 9 (7), pp.2357-2370. ⟨10.1039/c0ob00832j⟩. ⟨hal-00991910⟩
Emilia Paunescu, Ludivine Louise, Ludovic Jean, Anthony Romieu, Pierre-Yves Renard. A versatile access to new halogenated 7-azidocoumarins for photoaffinity labeling: Synthesis and photophysical properties. Dyes and Pigments, 2011, 91 (3), pp.427-434. ⟨10.1016/j.dyepig.2011.05.008⟩. ⟨hal-01017388⟩
Tristan Verdelet, Guillaume Mercey, Nobi Correa, Ludovic Jean, Pierre-Yves Renard. Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals. Tetrahedron, 2011, 67 (45), pp.8757-8762. ⟨10.1016/j.tet.2011.09.024⟩. ⟨hal-01017528⟩
Lucie Aliouane, Baptiste Rigaud, Emmanuel Pfund, Ludovic Jean, Pierre-Yves Renard, et al.. Synthesis of difluoromethylphosphonamidates by direct addition of amine. Tetrahedron Letters, 2011, 52 (28), pp.3681-3685. ⟨10.1016/j.tetlet.2011.05.034⟩. ⟨hal-01017309⟩
Cyril Ronco, Ludovic Jean, Hakim Outaabout, Pierre-Yves Renard. Palladium-Catalyzed Preparation of N-Alkylated Tacrine and Huprine Compounds. European Journal of Organic Chemistry, 2011, 2011 (2), pp.302-310. ⟨10.1002/ejoc.201001158⟩. ⟨hal-01017284⟩
Ludovic Jean, Michael Pouliquen, Jérôme Blanchet, Marie-Claire Lasne, Jacques Rouden. Synthesis of P,N-2,2′-biphenyl derivatives with central chirality. Science China Chemistry, 2010, 53 (9), pp.1907. ⟨10.1007/s11426-010-4056-2⟩. ⟨hal-00915655⟩
Cyril Ronco, Ludovic Jean, Pierre-Yves Renard. Improved synthetic pathway for the derivatization of huprine scaffold. Tetrahedron, 2010, 66 (37), pp.7399-7404. ⟨10.1016/j.tet.2010.07.021⟩. ⟨hal-01019278⟩
N. Fleury-Brégeot, Ludovic Jean, P. Retailleau, A. Marinetti. Screening of chiral phosphines as catalysts for the enantioselective (3+2) annulations of N-tosylimines with allenic esters. Tetrahedron, 2007, 63 (48), pp.11920-11927. ⟨10.1016/j.tet.2007.09.022⟩. ⟨hal-00221434⟩
Ludovic Jean, A. Marinetti. Phosphine-catalyzed enantioselective [3+2] annulations of 2,3-butadienoates with imines. Tetrahedron Letters, 2006, 47(13), pp.2141-2145. ⟨10.1016/j.tetlet.2006.01.122⟩. ⟨hal-00097813⟩

Communications dans un congrès11 document

Ludovic Jean. Design, biological evaluation and X-ray crystallography of multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. Société de Chimie Thérapeutique - Young Research Fellows Meeting (YRFM, 27, 2020), Jan 2020, Caen, France. ⟨hal-02544418⟩
T. Zorbaz, M. Katalinic, A. Zandona, Anissa Braïki, Ludovic Jean, et al.. Novel centrally active antidote for intoxication by sarin and VX nerve agents. Congress of the Federation-of-European-Biochemical-Societies (FEBS) on From Molecules to Cells and Back (42, 2017), Sep 2017, Jérusalem, Israel. pp.242, ⟨10.1111/febs.14174⟩. ⟨hal-02024992⟩
Sovy Chao, Ludovic Jean, E. Krejci, Pierre-Yves Renard. Selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging. International Symposium on Cholinergic Mechanisms (ISCM, 15, 2017), Oct 2016, Marseille, France. pp.209, ⟨10.1111/jnc.13925⟩. ⟨hal-02024977⟩
E. David, C. Ronco, Ludovic Jean, X. Brazzolotto, F. Nachon, et al.. Hupresin, a new affinity resin to purify butyrylcholinesterase. International Symposium on Cholinergic Mechanisms (ISCM, 15, 2017), Oct 2016, Marseille, France. pp.210, ⟨10.1111/jnc.13925⟩. ⟨hal-02024979⟩
T. Zorbaz, M. Katalinic, I. Pavicic, Anissa Braïki, J. Renou, et al.. The effects of organophosphorus compounds and novel antidotes on human neuronal cells. International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.224-225. ⟨hal-02024991⟩
Monika Cieslikiewicz-Bouet, Sovy Chao, Ludovic Jean, R. Araoz, D. Servent, et al.. Toward an innovative treatment of Alzheimer's disease: Synthesis and evaluation of multi-target directed ligands (MTDLs) targeting acetylcholinesterase (AChE) and alpha7 nicotinic acetylchloline receptors (alpha7 nAChRs). International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.209-210. ⟨hal-02024978⟩
G. Santoni, E. de La Mora, J.-P. Colletier, Ludovic Jean, Y. Xu, et al.. Dynamic mapping of acetylcholinesterase for structural-dynamics based reactivator design. 12th International Meeting on Cholinesterases, Sep 2015, Elche, Spain. ⟨hal-02024984⟩
E. Oueis, Ronco C., F. Nachon, Cyrille Sabot, Ludovic Jean, et al.. Insights on two in situ click chemistry reactions for the synthesis of AChE inhibitors. International Meeting on Cholinesterases - Sixth International Conference on Paraoxonases (12, 2015), Sep 2015, Elche, Spain. ⟨hal-02379142⟩
Ludovic Jean. Uncharged reactivators of OP-inhibited human cholinesterases. International Conference on Chemical Biological Radiological and Nuclear agents (CBRN) - Research & Innovation (1, 2015), Mar 2015, Antibes, France. ⟨hal-02378505⟩
Ludovic Jean. Réactivateurs d'acetylcholinestérase. Journées scientifiques nucléaire radiologique biologique chimique et explosifs (NRBCE), Commissariat à l'Energie Atomique (CEA), Jan 2015, Saclay, France. ⟨hal-02378480⟩
Z. Kovarik, M. Katalinic, Ludovic Jean, Pierre-Yves Renard, Renou J., et al.. Evaluation of three novel hydroxypicolinaldehyde oximes as efficient uncharged reactivators of VX-inhibited human acetylcholinesterase. FEBS-EMBO Anniversary Conference, Federation of European Biochemical Societies, Aug 2014, Paris, France. pp.65, ⟨10.1111/febs.12919⟩. ⟨hal-02395537⟩

Poster de conférence9 document

Anissa Braïki, Julien Renou, Romain Mougeot, Florian Nachon, André-Guilhem Calas, et al.. Synthesis and evaluations of uncharged reactivators for cholinesterases inhibited by organophosphate agents. International Conference on Chemical Biological Radiological and Nuclear agents (CBRN) - Research & Innovation (3, 2019), May 2019, Nantes, France. ⟨hal-02543439⟩
Anissa Braïki, Julien Renou, Romain Mougeot, Florian Nachon, José Dias, et al.. Synthesis and in vitro and in vivo evaluations of New Uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents. Medical Chemical Defense Conference (MCDC, 17, 2019), Mar 2019, Munich, Germany. ⟨hal-02543452⟩
Nicolas Probst, Anissa Braïki, Pierre Warnault, Julien Renou, Catherine Gomez, et al.. Uncharged reactivators of cholinesterases inhibited by organophosphorus nerve agents.. International Meeting on Cholinesterases (13, 2018) and International Conference on Paraoxonases (7, 2018)), Sep 2018, Hradec Králové, Czech Republic. ⟨hal-02543467⟩
Anissa Braïki, Julien Renou, Romain Mougeot, Tamara Zorbaz, André-Guilhem Calas, et al.. New Uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents. International Conference on Chemical Biological Radiological nuclear Explosive - Research & Innovation (CBRNE, 2, 2017), May 2017, Lyon, France. ⟨hal-02544823⟩
Sovy Chao, Eric Krejci, Véronique Bernard, Jacqueline Leroy, Ludovic Jean, et al.. Selective and Sensitive Near-Infrared Fluorescent Probe for Acetylcholinesterases Imaging. International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. ⟨hal-02544874⟩
Sovy Chao, Killian Oukoloff, Monika Bouet, Diego Muñoz Torrero, Jacques-Philippe Colletier, et al.. Multi Target directed ligands for the treatment of Alzheimer’s disease. Rencontres internationales de chimie thérapeutique (RICT, 52, 2016), Jul 2016, Caen, France. ⟨hal-02544849⟩
Anissa Braïki, Julien Renou, Catherine Gomez, Romain Mougeot, Florian Nachon, et al.. Synthesis of new uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents. Tetrahedron Symposium (17, 2016), Jun 2016, Barcelone, Spain. ⟨hal-02544884⟩
Pierre Warnault, Julien Renou, Catherine Gomez, Guillaume Mercey, Tristan Verdelet, et al.. Uncharged Reactivators of cholinesterases Inhibited by organophosphorus nerve agents. International Meeting on Cholinesterases - Sixth International Conference on Paraoxonases (12, 2015), Sep 2015, Elche, Spain. ⟨hal-02544902⟩
Pierre Warnault, Julien Renou, Catherine Gomez, Guillaume Mercey, Tristan Verdelet, et al.. Design and Development of New Uncharged Reactivators of OP-Inhibited Cholinesterases. International Conference on Chemical Biological Radiological and Nuclear agents (CBRN) - Research & Innovation (1, 2015), Mar 2015, Antibes, France. ⟨hal-02544917⟩

Brevets4 document

O. Lockridge,, M.A. Larson,, S.H. Schopfer,, S.H. Hinrichs,, Florian Nachon, et al.. Composition and methods for the purification and production of butyrylcholinesterase.. France, Patent n° : PCT/US14/66373. 2014. ⟨hal-01150306⟩
Rachid Baati, Maria Klyachina, Valentin Nussbaum, Pierre-Yves Renard, Ludovic Jean, et al.. Novel uncharged reactivators against OP-inhibition of human acetylcholinesterase. France, Patent n° : EP13306584.7. 2013. ⟨hal-01150304⟩
Cyril Ronco, Pierre-Yves Renard, Ludovic Jean, Florian Nachon, Anthony Romieu. Preparation of 7,11-Methanocycloocta[b]quinoline derivative as highly functionalizable acetylcholinesterase inhibitors for treating neurological diseases. France, Patent n° : WO 2011124712 A1. 2011. ⟨hal-01150301⟩
Cedric Bouteiller, Franco Mariani Maurizio, Cyril Ronco, Pierre-Yves Renard, Ludovic Jean, et al.. Labeled huprine derivatives and their use in medical imaging. France, Patent n° : WO 2011124713 A1. 2011. ⟨hal-01150300⟩

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Articles dans une revue45 document

Communications dans un congrès11 document

Poster de conférence9 document

Brevets4 document